RAF Grimsby was initially opened as a satellite station for RAF Binbrook in November 1941. The station was officially named RAF Grimsby although the name of the nearby village Waltham was used by locals and servicemen.
Throughout the war the station was under 1 Group Bomber Command. Three squadrons served at RAF Grimsby during its operation: 142 Squadron, 100 Squadron and 550 Squadron.
The station was closed some weeks prior to the surrender of Germany and the hangars were used by No.35 MU for storage and the flying field reverted to back to agricultural use. Years later the A16 was being improved and a bypass for the village of Holton-le-Clay cut into a large proportion of the station.
Currently a memorial to 100 Squadron stands near the B1 Hangar, next to the northern entrance to Holton-le-Clay. There is a memorial for 550 Squadron at the now disused station RAF North Killingholme and 142 Squadron is said to have a memorial in North Africa.