In 1758 the 2nd Battalion of the 8th Regiment of Foot became an independent Regiment and renumbered as the 63rd Regiment of Foot. It was swiftly deployed to the West Indies for 5 years, during the Seven Year’s War capturing the island of Guadeloupe. In 1775 after 12 years garrison duty in Ireland the Regiment went to serve in the American Revolutionary War (1775-83) fighting at Bunker Hill, Brooklyn, Eutaw Springs, Brandywine and Fort Clinton. In 1782 all British Regiments without Royal titles were awarded county titles in order to aid recruitment therefore, the 63rd became the 63rd (West Suffolk) Regiment of Foot. The Regiment returned to the West Indies in 1795 to capture various French and Dutch controlled Islands during the French Revolutionary War. It returned to Europe in 1799 and took part in campaigns in the Netherlands and Portugal before returning to the West Indies in 1808 until 1819. In 1829 the Regiment escorted convict ships to New South Wales and Tasmania and remained on garrison duties there until 1833, when it was deployed to India and then on to Burma in 1838. The Regiment went on to serve during the Crimean War (1853–56) in 1854 fighting at the Battle of Inkerman and the Siege of Sevastopol.
In 1881 the Childers Reform restructured the British army infantry regiments into a network of multi-battalion regiments each having two regular and two militia battalions. The 63rd (West Suffolk) and 96th Regiments of Foot were amalgamated to form The Manchester Regiment.